![]() We examined the benefit of an SLN biopsy and adjuvant therapy on prognosis in Japanese patients with thick melanoma. The benefit of a sentinel lymph node (SLN) biopsy and adjuvant therapy for patients with thick (>4 mm) melanoma has not been well studied in the Asian population. The group of invasive melanomas presented with a higher frequency and statistical significance (p 4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients. RESULTS Among thin melanomas, the most frequent criteria were presence of asymmetry in two axes in 95% of cases (39 cases), 3 or more colors in 80.4% of cases (33 cases), atypical dots or globules in 58.5% of cases (24 cases) and atypical network or streaks in 53.6% of cases (22 cases). Three observers evaluated together 14 dermoscopic criteria. METHODS This was an observational retrospective study in which the dermoscopy photographs of 41 thin melanomas were evaluated. OBJECTIVES This study aims at describing the dermoscopic features of thin melanomas and comparing melanomas in situ with invasive melanomas less than or equal to 1 mm thick. The preoperative determination of Breslow index by dermoscopy could be useful in planning the surgical approach and in selecting patients for sentinel lymph node biopsy. However, further studies are necessary to answer such question as optimal treatment, combination of immunotherapies, crowd selection and risk balance in patients with melanoma.ĭermoscopic features of thin melanomas: a comparative study of melanoma in situ and invasive melanomas smaller than or equal to 1 mm*ĭa Silva, Vanessa Priscilla Martins Ikino, Juliana Kida Sens, Mariana Mazzochi Nunes, Daniel Holthausen Di Giunta, GabriellaīACKGROUND Dermoscopy allows the early detection of melanomas. The combination of immunotherapy provides new options for the treatment of MM patients. In this review, recently immunotherapy clinical trial results are presented. The combination immunotherapy seems to be superior to monotherapy. Ipilimumab and pembrolizumab, monoclonal antibodies against the CTLA-4 and PD-1 respectively, have been shown to prolong overall survival (OS) in patients with advanced melanoma. Immune checkpoints show the revolutionary treatment of metastatic melanoma. Advanced MM still has a poor prognosis, but in recent years, the development of immunotherapy has changed its poor prognosis. Malignant melanoma ( MM) is the primary cause of skin cancer related death and the incidence is increasing in the past years. Immunotherapy of patients with metastatic melanoma. The relatively high incidence of both melanoma deaths and regional node metastases for the BANS group merits consideration for testing the efficacy of elective regional node dissection for these patients. This compared with six deaths from melanoma in 16 patients (37.5%) with level IV BANS lesions (5/51 vs 6/16, p = 0.01 Fisher's Exact Test). Of the 67 BANS patients, 51 had level II or level III lesions and five (10%0 died of melanoma. There has been only one death from melanoma in 136 patients with melanoma located at other sites (11/67 vs 1/136, p less than 0.0001 Fisher's Exact Test). ![]() Of the 12 deaths from melanoma, 11 occurred in patients with primary tumors located on the upper back, posterior arm, posterior neck, and posterior scalp (=BANS). Only two variables, primary tumor location and level of invasion, were useful in predicting death from melanoma for these patients. An appraisal of "thin" level IV lesions.ĭay, C L Mihm, M C Sober, A J Harris, M N Kopf, A W Fitzpatrick, T B Lew, R A Harrist, T J Golomb, F M Postel, A Hennessey, P Gumport, S L Raker, J W Malt, R A Cosimi, A B Wood, W C Roses, D F Gorstein, F Rigel, D Friedman, R J Mintzis, M Mįourteen variables were tested for their prognostic usefulness in 203 patients with clinical Stage I melanoma and primary tumor 0.76-169 mm thick. Prognostic factors for melanoma patients with lesions 0.76 - 1.69 mm in thickness. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |